Histone modification defects in developmental disorders and cancer
نویسندگان
چکیده
منابع مشابه
Histone modification defects in developmental disorders and cancer
Clinically, Weaver syndrome is closely related to Sotos syndrome, which is frequently caused by mutations in NSD1. This gene also encodes a histone methyltransferase, in this case with activity against histone H3 lysine 36. NSD1 is mutated in carcinoma of the upper aerodigestive tract (www.sanger.ac.uk/genetics/CGP/cosmic/) and also fuses to NUP98 in acute myeloid leukemia. Looking more widely,...
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Histone lysine methylation plays a critical role in epigenetic regulation of eukaryotes. To date, studies have shown that lysine residues of K4, K9, K27, K36 and K79 in histone H3 and K20 in histone H4 can be modified by histone methyltransferases (HMTs). Such histone methylation can specifically activate or repress the transcriptional activity to play a key role in gene expression/regulation a...
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the epigenetic alterations like histone modifications , dna methylation and others remarkable categories including nucleosome remodeling and rna mediated targeting have been strongly investigated recently .in this way , beside the notable importance of dna methylation ,the histone modifications are the most important issues in the tumorogenesis and cancer progression. moreover, the fluctuati...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2012
ISSN: 1949-2553
DOI: 10.18632/oncotarget.436